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Title: Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence
Authors: Sturm, Jonathan
Golledge, J.
Clancy, P.
Maguire, J.
Lincz, L.
Koblar, Simon A
McEvoy, M.
Attia, J.
Levi, C.R.
Almeida, O.P.
Yeap, B.B.
Flicker, L.
Norman, P.E.
Hankey, G.J.
Keywords: Neurology;Stroke
Year: Apr-2014
Citation: Volume 45, Issue 4, pp. 1064 - 1068
Abstract: BACKGROUND AND PURPOSE: Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS: Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS: Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. CONCLUSIONS: Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes.
ISSN: 1524-4628
DOI: 10.1161/STROKEAHA.113.004339
Journal Title: Stroke
Appears in Collections:Neurology

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