Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1292
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSturm, Jonathanen
dc.contributor.otherGolledge, J.en
dc.contributor.otherClancy, P.en
dc.contributor.otherMaguire, J.en
dc.contributor.otherLincz, L.en
dc.contributor.otherKoblar, Simon Aen
dc.contributor.otherMcEvoy, M.en
dc.contributor.otherAttia, J.en
dc.contributor.otherLevi, C.R.en
dc.contributor.otherAlmeida, O.P.en
dc.contributor.otherYeap, B.B.en
dc.contributor.otherFlicker, L.en
dc.contributor.otherNorman, P.E.en
dc.contributor.otherHankey, G.J.en
dc.date.accessioned2019-03-19T04:28:01Zen
dc.date.available2019-03-19T04:28:01Zen
dc.date.issued2014-04en
dc.identifier.citationVolume 45, Issue 4, pp. 1064 - 1068en
dc.identifier.issn1524-4628en
dc.identifier.urihttps://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1292en
dc.description.abstractBACKGROUND AND PURPOSE: Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome. METHODS: Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined. RESULTS: Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26-9.53 compared with 17.36; interquartile range, 14.01-22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81-8.75 ng/mL for modified Rankin scale 3-6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75-9.92 ng/mL for modified Rankin scale 0-2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men. CONCLUSIONS: Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes.en
dc.subjectNeurologyen
dc.subjectStrokeen
dc.titlePlasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidenceen
dc.typeJournal Articleen
dc.identifier.doi10.1161/STROKEAHA.113.004339en
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/24569814en
dc.identifier.journaltitleStrokeen
dc.originaltypeTexten
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
Appears in Collections:Neurology
Show simple item record

Page view(s)

38
checked on Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.