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Title: High rates of sexually transmissible infections in HIV-positive patients in the Australian HIV Observational Database: a prospective cohort study
Authors: Allen, Debra M
Smith, David J
Mulhall, B.P.
Wright, S.
Brown, K.
Dickson, B.
Grotowski, M.
Jackson, E.
Petoumenos, K.
Read, P.
Russell, D.
Templeton, D.J.
Fairley, C.K.
Law, M.G.
Keywords: Public Health;Infection
Year: Sep-2014
Citation: Volume 11, Issue 4, pp. 291 - 297
Abstract: UNLABELLED: Background In HIV-positive people, sexually transmissible infections (STIs) probably increase the infectiousness of HIV. METHODS: In 2010, we established a cohort of individuals (n=554) from clinics in the Australian HIV Observational Database (AHOD). We calculated retrospective rates for four STIs for 2005-10 and prospective incidence rates for 2010-11. RESULTS: At baseline (2010), patient characteristics were similar to the rest of AHOD. Overall incidence was 12.5 per 100 person-years. Chlamydial infections increased from 3.4 per 100 person-years (95% confidence interval (CI): 1.9-5.7) in 2005 to 6.7 per 100 person-years (95% CI: 4.5-9.5) in 2011, peaking in 2010 (8.1 per 100 person-years; 95% CI: 5.6-11.2). Cases were distributed among rectal (61.9%), urethral (34%) and pharyngeal (6.3%) sites. Gonococcal infections increased, peaking in 2010 (4.7 per 100 person-years; 95% CI: 5.6-11.2; Ptrend=0.0099), distributed among rectal (63.9%), urethral (27.9%) and pharyngeal (14.8%) sites. Syphilis showed several peaks, the largest in 2008 (5.3 per 100 person-years; 95% CI: 3.3-8.0); the overall trend was not significant (P=0.113). Genital warts declined from 7.5 per 100 person-years (95% CI: 4.8-11.3) in 2005 to 2.4 per 100 person-years (95% CI: 1.1-4.5) in 2011 (Ptrend=0.0016). CONCLUSIONS: For chlamydial and gonococcal infections, incidence was higher than previous Australian estimates among HIV-infected men who have sex with men, increasing during 2005-2011. Rectal infections outnumbered infections at other sites. Syphilis incidence remained high but did not increase; that of genital warts was lower and decreased.
ISSN: 1448-5028
DOI: 10.1071/sh13074
Journal Title: Sexual Health
Appears in Collections:Health Service Research

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