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Title: Outpatient rituximab, ifosfamide, etoposide (R-IE) in patients older than 60 years with relapsed or refractory diffuse large B-cell lymphoma who are not candidates for stem cell transplantation
Authors: Forsyth, Cecily J
Joshi, M.
Taper, J.
Rowlings, P.
Campbell, P.
Crispin, P.
Harvey, M.
Underhill, C.
Bayley, A.
Byth, K.
Huang, G.
Hertzberg, M.
Keywords: Haematology;Hematology;Cancer
Year: Sep-2019
Citation: Epub ahead of print
Abstract: Patients with relapsed-refractory diffuse large B-cell lymphoma (RR-DLBCL) ineligible for autologous stem cell transplantation (autoSCT) have poor survival. Thirty transplant-ineligible patients older than 60 years were administered rituximab 375 mg/m2 day 1, ifosfamide 1333 mg/m(2) days 1 to 3, and etoposide 80 mg/m(2) days 1 to 3 (R-IE) every 21 days for 6 cycles plus 2 doses of rituximab. Revised international prognostic index 3-4 was seen in 53% and prior rituximab exposure in 60%. The complete and overall response rates were 55% and 76%, respectively. Median progression free survival (PFS) and overall survival were 23 and 24 months, respectively. Patients relapsing within 12 months of prior treatment had a median PFS of 2.5 months compared to 23 months for those relapsing beyond 12 months. Grade 3-4 thrombocytopenia and neutropenia occurred in one and eight patients, respectively. R-IE is an effective, well tolerated regimen in RR-DLBCL patients not fit for autoSCT.
ISSN: 1026-8022
DOI: 10.1080/10428194.2019.1660968
Journal Title: Leukemia & Lymphoma
Appears in Collections:Haematology

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