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Title: Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes
Authors: O'Mullane, Phebe
Isbister, G.K.
Murray, L.
John, S.
Hackett, L.P.
Haider, T.
Gosselin, S.
Daly, F.
Keywords: Cardiology;Mental Health
Year: Apr-2006
Citation: Volume 184, Issue 7, pp. 354 - 356
Abstract: Although clinical trials of the antipsychotic amisulpride revealed no cardiac adverse effects, four patients with severe cardiac toxicity after overdose were reported to Australian poisons information centres in 2004-2005. All four had QT prolongation over 500 ms, two had rate-dependent bundle branch block, two developed torsades de pointes, and one died after cardiac arrest. Pending further studies, we recommend electrocardiogram assessment until at least 16 h after amisulpride overdose and, if QT interval is prolonged, cardiac monitoring until the patient is clinically well and conduction intervals are normal.
ISSN: 0025-729x
Journal Title: The Medical Journal of Australia
Appears in Collections:Cardiology

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