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Title: | Single- Versus 2-Stent Strategies for Coronary Bifurcation Lesions: A Systematic Review and Meta-Analysis of Randomized Trials With Long-Term Follow-up | Authors: | Ford, Tom ;McCartney, P.;Corcoran, D.;Collison, D.;Hennigan, B.;McEntegart, M.;Hildick-Smith, D.;Oldroyd, K.G.;Berry, C. | Affliation: | Central Coast Local Health District Gosford Hospital |
Issue Date: | May-2018 | Source: | 7(11):e008730 | Journal title: | Journal of the American Heart Association | Department: | Cardiology | Abstract: | BACKGROUND: The majority of coronary bifurcation lesions are treated with a provisional single-stent strategy rather than an up-front 2-stent strategy. This approach is supported by multiple randomized controlled clinical trials with short- to medium-term follow-up; however, long-term follow-up data is evolving from many data sets. METHODS AND RESULTS: Meta-analysis of randomized controlled trials evaluating long-term outcomes (>/=1 year) according to treatment strategy for coronary bifurcation lesions. Nine randomized controlled trials with 3265 patients reported long-term clinical outcomes at mean weighted follow-up of 3.1+/-1.8 years. Provisional single stenting was associated with lower all-cause mortality (2.94% versus 4.23%; risk ratio: 0.69; 95% confidence interval, 0.48-1.00; P=0.049; I(2)=0). There was no difference in major adverse cardiac events (15.8% versus 15.4%; P=0.79), myocardial infarction (4.8% versus 5.5%; P=0.51), target lesion revascularization (9.3% versus 7.6%; P=0.19), or stent thrombosis (1.8% versus 1.6%; P=0.28) between the groups. Prespecified sensitivity analysis of long-term mortality at a mean of 4.7 years of follow-up showed that the provisional single-stent strategy was associated with reduced all-cause mortality (3.9% versus 6.2%; risk ratio: 0.63; 95% confidence interval, 0.42-0.97; P=0.036; I(2)=0). CONCLUSIONS: Coronary bifurcation percutaneous coronary intervention using a provisional single-stent strategy is associated with a reduction in all-cause mortality at long-term follow-up. | URI: | https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1567 | DOI: | 10.1161/JAHA.118.008730 | Pubmed: | https://www.ncbi.nlm.nih.gov/pubmed/29802145 | ISSN: | 2047-9980 | Publicaton type: | Journal Article | Keywords: | Heart Disease Cardiology Cardiovascular Disease |
Study or Trial: | Reviews/Systematic Reviews |
Appears in Collections: | Cardiology |
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