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Please use this identifier to cite or link to this item: https://hdl.handle.net/1/1578
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dc.contributor.authorSturm, Jonathanen
dc.contributor.authorMaguire, Jane Men
dc.contributor.otherHolliday, E.G.en
dc.contributor.otherEvans, T.J.en
dc.contributor.otherKoblar, Simon Aen
dc.contributor.otherJannes, J.en
dc.contributor.otherHankey, G.J.en
dc.contributor.otherBaker, R.en
dc.contributor.otherGolledge, J.en
dc.contributor.otherParsons, M.W.en
dc.contributor.otherMalik, R.en
dc.contributor.otherMcEvoy, M.en
dc.contributor.otherBiros, E.en
dc.contributor.otherLewis, M.D.en
dc.contributor.otherLincz, L.F.en
dc.contributor.otherPeel, R.en
dc.contributor.otherOldmeadow, C.en
dc.contributor.otherSmith, W.en
dc.contributor.otherMoscato, P.en
dc.contributor.otherBarlera, S.en
dc.contributor.otherBevan, S.en
dc.contributor.otherBis, J.C.en
dc.contributor.otherBoerwinkle, E.en
dc.contributor.otherBoncoraglio, G.B.en
dc.contributor.otherBrott, T.G.en
dc.contributor.otherBrown, R.D., Jren
dc.contributor.otherCheng, Y.C.en
dc.contributor.otherCole, J.W.en
dc.contributor.otherCotlarciuc, I.en
dc.contributor.otherDevan, W.J.en
dc.contributor.otherFornage, M.en
dc.contributor.otherFurie, K.L.en
dc.contributor.otherGretarsdottir, S.en
dc.contributor.otherGschwendtner, A.en
dc.contributor.otherIkram, M.A.en
dc.contributor.otherLongstreth, W.T., Jr.en
dc.contributor.otherMeschia, J.F.en
dc.contributor.otherMitchell, B.D.en
dc.contributor.otherMosley, T.H.en
dc.contributor.otherNalls, M.A.en
dc.contributor.otherParati, E.A.en
dc.contributor.otherPsaty, B.M.en
dc.contributor.otherSharma, P.en
dc.contributor.otherStefansson, K.en
dc.contributor.otherThorleifsson, G.en
dc.contributor.otherThorsteinsdottir, U.en
dc.contributor.otherTraylor, M.en
dc.contributor.otherVerhaaren, B.F.en
dc.contributor.otherWiggins, K.L.en
dc.contributor.otherWorrall, B.B.en
dc.contributor.otherSudlow, C.en
dc.contributor.otherRothwell, P.M.en
dc.contributor.otherFarrall, M.en
dc.contributor.otherDichgans, M.en
dc.contributor.otherRosand, J.en
dc.contributor.otherMarkus, H.S.en
dc.contributor.otherScott, R.J.en
dc.contributor.otherLevi, C.en
dc.contributor.otherAttia, J.en
dc.date.accessioned2019-08-05T02:37:35Zen
dc.date.available2019-08-05T02:37:35Zen
dc.date.issued2012-10en
dc.identifier.citationVolume 44, Issue 10, pp. 1147 - 1151en
dc.identifier.issn1546-1718en
dc.identifier.urihttps://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/1578en
dc.description.abstractGenome-wide association studies (GWAS) have not consistently detected replicable genetic risk factors for ischemic stroke, potentially due to etiological heterogeneity of this trait. We performed GWAS of ischemic stroke and a major ischemic stroke subtype (large artery atherosclerosis, LAA) using 1,162 ischemic stroke cases (including 421 LAA cases) and 1,244 population controls from Australia. Evidence for a genetic influence on ischemic stroke risk was detected, but this influence was higher and more significant for the LAA subtype. We identified a new LAA susceptibility locus on chromosome 6p21.1 (rs556621: odds ratio (OR)=1.62, P=3.9x10(-8)) and replicated this association in 1,715 LAA cases and 52,695 population controls from 10 independent population cohorts (meta-analysis replication OR=1.15, P=3.9x10(-4); discovery and replication combined OR=1.21, P=4.7x10(-8)). This study identifies a genetic risk locus for LAA and shows how analyzing etiological subtypes may better identify genetic risk alleles for ischemic stroke.en
dc.subjectStrokeen
dc.subjectBrainen
dc.subjectNeurologyen
dc.subjectGenetic Diseasesen
dc.titleCommon variants at 6p21.1 are associated with large artery atherosclerotic strokeen
dc.typeJournal Articleen
dc.identifier.doi10.1038/ng.2397en
dc.description.pubmedurihttps://www.ncbi.nlm.nih.gov/pubmed/22941190en
dc.identifier.journaltitleNature Geneticsen
dc.type.studyortrialMeta-Analysisen
dc.originaltypeTexten
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
Appears in Collections:Neurology
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