Please use this identifier to cite or link to this item: https://hdl.handle.net/1/208
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dc.contributor.authorLucock, M.en
dc.contributor.authorYates, Z.en
dc.contributor.authorNg, Xiaoweien
dc.contributor.authorVeysey, Martinen
dc.contributor.authorBlades, Barbaraen
dc.contributor.authorTravers, Cherylen
dc.contributor.authorLewis, Peter Ren
dc.contributor.authorSturm, Jonathanen
dc.contributor.authorRoach, Paulen
dc.date.accessioned2015-04-13T23:19:28Zen
dc.date.available2015-04-13T23:19:28Zen
dc.date.issued2008-01en
dc.identifier.citationVolume 1, Issue 1-2, pp. 22-29en
dc.identifier.issn1661-6499en
dc.identifier.urihttps://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/208en
dc.description.abstractBACKGROUND/AIMS: Folic acid mediates transfer of one-carbon units into methionine and DNA-thymine biosynthesis. Discretionary and mandatory use of synthetic folic acid (SFA) to reduce spina bifida is on the increase. We show that historically, the seasonal cycle of abundance of folate-rich foods may have regulated embryo viability by acting as a selection factor for a significant polymorphism within a gene encoding 5,10-methylenetetrahydrofolate reductase (677C-->T-MTHFR). METHODS: Blood was collected from 150 UK and 118 Australian subjects born prior to discretionary or mandatory use of SFA. 677C-->T-MTHFR genotype was determined using PCR. RESULTS: The highest prevalence for 677T-MTHFR occurred 9 months post-harvest in UK subjects and was significantly higher at this time of year (July-Sept.) compared with Jan.-Mar. (OR = 2.0, 95% CI 1.03-3.87, p = 0.039) and Oct.-Dec. (OR = 2.2, 95% CI 1.12-4.31, p = 0.021). This effect was not detected in an Australian population subject to more moderate seasonality. CONCLUSIONS: Dietary folate may confer significant genetic buffering within populations dependent upon seasonal food sources that modify an individual's vitamin status at the time of conception.en
dc.subjectGenotypeen
dc.subjectNutritionen
dc.subjectObstetricsen
dc.titlePreliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundanceen
dc.typeJournal Articleen
dc.identifier.doi10.1159/000109872en
dc.description.pubmedurihttp://www.ncbi.nlm.nih.gov/pubmed/19918112en
dc.identifier.journaltitleJournal of Nutrigenetics and Nutrigenomicsen
dc.originaltypeTexten
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone-
Appears in Collections:Gastroenterology
Neurology
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