Please use this identifier to cite or link to this item:
https://hdl.handle.net/1/208
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DC Field | Value | Language |
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dc.contributor.author | Lucock, M. | en |
dc.contributor.author | Yates, Z. | en |
dc.contributor.author | Ng, Xiaowei | en |
dc.contributor.author | Veysey, Martin | en |
dc.contributor.author | Blades, Barbara | en |
dc.contributor.author | Travers, Cheryl | en |
dc.contributor.author | Lewis, Peter R | en |
dc.contributor.author | Sturm, Jonathan | en |
dc.contributor.author | Roach, Paul | en |
dc.date.accessioned | 2015-04-13T23:19:28Z | en |
dc.date.available | 2015-04-13T23:19:28Z | en |
dc.date.issued | 2008-01 | en |
dc.identifier.citation | Volume 1, Issue 1-2, pp. 22-29 | en |
dc.identifier.issn | 1661-6499 | en |
dc.identifier.uri | https://elibrary.cclhd.health.nsw.gov.au/cclhdjspui/handle/1/208 | en |
dc.description.abstract | BACKGROUND/AIMS: Folic acid mediates transfer of one-carbon units into methionine and DNA-thymine biosynthesis. Discretionary and mandatory use of synthetic folic acid (SFA) to reduce spina bifida is on the increase. We show that historically, the seasonal cycle of abundance of folate-rich foods may have regulated embryo viability by acting as a selection factor for a significant polymorphism within a gene encoding 5,10-methylenetetrahydrofolate reductase (677C-->T-MTHFR). METHODS: Blood was collected from 150 UK and 118 Australian subjects born prior to discretionary or mandatory use of SFA. 677C-->T-MTHFR genotype was determined using PCR. RESULTS: The highest prevalence for 677T-MTHFR occurred 9 months post-harvest in UK subjects and was significantly higher at this time of year (July-Sept.) compared with Jan.-Mar. (OR = 2.0, 95% CI 1.03-3.87, p = 0.039) and Oct.-Dec. (OR = 2.2, 95% CI 1.12-4.31, p = 0.021). This effect was not detected in an Australian population subject to more moderate seasonality. CONCLUSIONS: Dietary folate may confer significant genetic buffering within populations dependent upon seasonal food sources that modify an individual's vitamin status at the time of conception. | en |
dc.subject | Genotype | en |
dc.subject | Nutrition | en |
dc.subject | Obstetrics | en |
dc.title | Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance | en |
dc.type | Journal Article | en |
dc.identifier.doi | 10.1159/000109872 | en |
dc.description.pubmeduri | http://www.ncbi.nlm.nih.gov/pubmed/19918112 | en |
dc.identifier.journaltitle | Journal of Nutrigenetics and Nutrigenomics | en |
dc.originaltype | Text | en |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Journal Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
Appears in Collections: | Gastroenterology Neurology |
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