Please use this identifier to cite or link to this item: https://hdl.handle.net/1/2736
Title: Glucose levels at hospital admission are associated with 5 year mortality
Authors: Cheung, N Wah;McElduff, Patrick;Fulcher, Greg;Middleton, Sandy;Chen, Roger;Depczynski, Barbara;Flack, Jeff;Kinsella, Jen M ;Layton, Margaret ;McLean, Mark;Poynten, Ann;Tonks, Katherine;White, Chris;Wong, Vincent;Chipps, David R
Affliation: Central Coast Local Health District
Gosford Hospital
Issue Date: 30-Aug-2024
Source: Online ahead of print
Journal title: Diabetes Research and Clinical Practice
Department: Diabetes, Endocrinology & Metabolism
Abstract: We aimed to determine if hospital admission hyperglycaemia and hypoglycaemia are associated with increased long-term mortality. A post-hoc analysis of data from a trial of glucose screening in the emergency department was conducted. Data were linked with a death registry up to 5 years after admission. The relationship between admission glucose and mortality was examined by cox regression. Further analyses of people who survived the admission and subsequent 28 days was performed. There were 131,322 patients, of whom 38,712 (29.5 %) died. Mean follow-up was 3·3 ± 1·5 years. Compared to the reference glucose band of 6·1-8·0 mmol/L, there was increased mortality in higher bands, reaching a hazard ratio (HR) of 1·44 (95 %CI 1·34-1·55, p < 0·001) for people with glucose > 20·0 mmol/L. The HR was 1·56 (95 %CI 1·46-1·68, p < 0·001) for people with glucose ≤ 4·0 mmol/L. Similar relationships were observed among 28-day survivors. The relationships were attenuated among people with known diabetes. Among 4867 subjects with glucose ≥ 14·0 mmol/L, those diagnosed with diabetes during the admission had lower mortality compared to subjects where the diagnosis was not made (HR 0·53, 95 %CI 0·40-0·72, p < 0·001). This was attenuated among 28-day survivors. Hyperglycaemia and hypoglycaemia on hospital admission are associated with increased long-term mortality.
URI: https://hdl.handle.net/1/2736
DOI: 10.1016/j.diabres.2024.111840
Pubmed: https://pubmed.ncbi.nlm.nih.gov/39216794
Publicaton type: Journal Article
Keywords: Diabetes
Appears in Collections:Health Service Research

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